The existential crisis of being an interdisciplinary scientist.

Two days ago, I was called a physicist.
Not that I find that an insult, quite the contrary. I have been called a physicist before, just not by another physicist. My working environment consists almost solely of biologists, of all sorts and kinds, and on occasion when I walk in a room or join a table, a conversation much like this one would start:

“You’re a physicist, right?”

“Not really, well sort of, I guess.”

“So, is it better wrap food with the shiny part of aluminium foil on the inside.” Or another physicky question I don’t actually know the answer to.

But the thing is, I would never describe myself as a physicist. And I always had the impression that even if biologists would describe me as a physicist, physicist would rather describe me as a biologist. I don’t consider myself a biologist either.
So when two days ago a physicist said to me: “I see you as a physicist,” I got catapulted into an existential crisis.
Who am I? is a philosophical question and difficult enough. Now I was asking myself asking: What am I?
Yeah, human. A bunch of cells organised into tissues and organs and a body. A set of connections and bioelectrical signals making up a consciousness. But I don’t think that will qualify as a good answer at, say, a future job interview.
I have recently described myself – during my debut as a stand-up comedian(*) – as an inbetweener (no, not one of these). My research lies on the interface between biology/life science and physics/engineering. The whole point of the project I’m in, is to create a new cohort of interdisciplinary scientists that are able to talk to both biologists or clinicians, and physicists, essentially bridging the gap between both worlds. If you’re wondering why interdisciplinary research is even worth pursuing, a recent Nature special does a pretty good job describing the advantages (and current issues). Note that one of the ways to promote interdisciplinary research is: “Invest in interdisciplinary PhD cohorts, co-supervised by academics from diverse departments or faculties.” Exactly.
But my point is that, most of the time, people undertaking interdisciplinary research have a solid background in one particular field. You might have heard of physicists merging into biology or biologists dabbling in physics. Most of the people in my program fall in this category, they are either physicists or biologists and doing research on the interface.
But not me. I started out interdisciplinary. I usually describe myself as a bio-engineer, even though that’s not really what my MSc diploma says (but no matter what I say -“nanotechnologist, “bionanotechnologist” or “bio-engineer” – it almost always merits further explanation and I feel the latter describes me best). Unfortunately, a test linked to that recent Nature special tells me that “I am not truly an interdisciplinary scientist, I am able to talk about different subject but to not have the core understanding of all of them.” If this is correct – assuming online tests have some fraction of truth – shouldn’t I then have a core understanding in one field? What would that field even be?
I sometimes *jokingly* say that as a bio-engineer, I know a bit about a lot of different things, but never a lot about one thing. I then *jokingly* say that this is *very useful*. This sarcasm is quite often true; I’m constantly reminded of gaps in my knowledge. Fortunately, I am occasionally reminded of the advantages of my background. I know of a lot of things. I’m capable of absorbing a lot of information in relatively short amounts of time because I have a basic understanding of the lingo and concepts in all these various fields. I have a certain way of approaching a problem. As I have pointed out in a previous post, I am an engineer, trust me, and that comes with a certain mindset and way of thinking, and probably the type of mind that has difficulty asking for help and is socially awkward. Hmm, *very useful*.
Which leads to another existential question: Did I study engineering because I have an engineering-type mind, or did studying engineering develop my engineery mind? It’s the nature-nurture debate. And the answer is probably also: most likely a combination of both.
Maybe all interdisciplinary scientists go through existential crises sometimes, because they’re never really sure where they fit in best. Luckily not fitting in isn’t always a bad thing.
I’m not sure if I made any progress on answering the question What am I?, but I’m thinking about myself and I guess that’s part of a PhD as well; it’s not only about science, it’s also a path of self-discovery.

In other news, I seem to have had an overdose of Mars in the past few weeks: I finished reading Brian Cox’s Human Universe, where he states that space exploration and sending humans to Mars is basically a must (if you consider how much advancement moon exploration has helped our advance), they have discovered evidence of water on mars (Dont’t drink the water. Don’t even touch it. Not one drop.), I saw The Martian the day before NASA published a document outlining their strategy to send people up there. It makes me wish I never gave up on my dream to become an astronaut (when I was about 8, and realised that there’s no way someone scared of dogs could be a vet).

(*) I have no real plans of becoming a stand-up comedian, it was just a really awesome and scary thing I tried recently.

# Trust Me I’m An Engineer

Some time ago, on my usually waste-of-time website, I found a post about the first female engineer. As a female engineer – let’s not go into whether that’s self-proclaimed or not – , I naturally wanted to find out more.
First, it seemed necessary to find a definition for “engineering”.
As so many other words, engineering is derived from Latin. It can have originated from either – or perhaps both – ingenium or – and – ingeniare. As the word ingenious might hint, the first means something in the lines of cleverness, though I’ve also seen it translated as talent; the latter means to devise (according to wikipedia, I had more trouble finding the word through other sources). The stem of the word seems to resemble ingenerare (to implant) and ingenere (to instill by birth). Therefore it seems that the word initially meant something along the lines of having a natural talent for something but slowly evolved to coming up with clever tricks or solutions to solve a certain problem.
Nowadays, the current official definition of “engineering” is (according to Engineers’ Council for Professional Development):

The creative application of scientific principles to design or develop structures, machines, apparatus, or manufacturing processes, or works utilising them singly or in combination; or to construct or operate the same with full cognisance of their design; or to forecast their behaviour under specific operating conditions; all as respects an intended function, economics of operation or safety to life and property.

Hmmm, that’s one of those sentences that I still haven’t completely grasped after reading it three times and then I usually just give up. Let’s give that definition another try then. According to my understanding (and self-proclaimed experience), engineers aim to design (or invent, or optimize, or improve) something by the application of scientific and mathematical principles. This something can range from materials, instruments, software, living systems, you name it; basically anything that you can imagine inventing or improving on.
It differs from science mostly due to the fact that sciences aim to build on knowledge starting from predictions and hypotheses about the universe (or, anything).
If this not making much sense… Well, probably this comic by Saturday Morning Breakfast Cereal does a better job on describing the essence of engineering:

So, I guess you can say that engineers are more interested in applying scientific knowledge to whatever they are working, while scientists are more aimed at acquiring said knowledge. In my opinion (and again, “experience”) the distinction between the two is not always very straight cut, and a lot of people are more somewhere in between, say applied scientist, or scientific engineers, or engineering scientist (though that last one sounds more like someone trying to create a race of super-scientists through genetic engineering). I also think it’s quite obvious that both (or all people on that spectrum) need each other to achieve progress.
Nevertheless, my post was going to be about the first female engineer. Because whichever way you look at it, women are still underrepresented in these fields, even if the situation is already much more balanced than it used to be. It also strongly depends on the type of engineering. For example, while there are about 50% of women studying bio-engineering or architectural engineering at my formal school, only 15% of engineering (that later splits into mechanical, civil, chemical, biomedical, computer, and mathematical engineering) consists of female students. Perhaps “us girls” just need some role models?
The first candidate-rolemodel, and the “first female engineer” according to that post I mentioned, is Elisa Leonida Zamfirescu.

Elisa Leonida Zamfirescu

Elisa was born in 1887 in Romania, in a quite engineery – yes that is a word, stop it red squiggly line – family.  Her grandfather, on her mother’s side, was an engineer and so was her older brother Dimitrie. I imagine her as a child inventor, a bit like Violet Baudelaire, who did not give up after being rejected from engineering school (School of Bridges and Roads in Bucharest). No, she just applied to other schools, and in 1909, she was accepted at the Royal Academy of Technology Berlin. Three years later, she graduated, and started her career in geology laboratories back in Romania. She passed the war years (World War I) in the Red Cross, around which time she met her husband, Constantin Zamfirescu, a chemist.  She spent her engineering career leading several geology labs in the Geological Institute in Romania and teaching physics and chemistry. Her contributions include her role in identifying new resources of coal, natural gas and copper. She worked until she was 75, and died in 1973.
Despite her contributions to the world of engineering, Elisa was not technically the first engineer. Alice Jacqueline Perry, an Irish cailín born in 1885, graduated a few years before. Her family sounds very well educated; her father was co-founder of the Galway Electric Light Company as well as county surveyor for the County Council and her uncle invented the navigational gyroscope (two of her sisters also continued into higher education, by the way), Alice was quite a mathlete, or would have been if they had those in the 1900s.

Alice Jacqueline Perry

She received a scholarship to study at the Queen’s College in Galway in 1902, where she pursued a degree in engineering. She graduated in 1906, with first class honours. Alice was the first female engineering graduate in Ireland, the UK, and in my understanding, the world. A month after her graduation, her father’s death caused her to take up his position temporarily for County Council, making her the only woman to have been a County Surveyor – basically a Council Engineer – in Ireland. She moved to London in 1908, starting a job as a Lady Factory Inspector. She moved to Glasgow in 1915 (and seemed to have continued an inspector job there as well). In 1921 she grew bored of engineering, and started writing poetry (eventually publishing seven books of poetry). She was heavily involved in the Christian Science movement, and moved to Boston headquarters in 1923, where she worked until her death in 1969, about a month after the moon landing.
These may seem like quite ordinary lives, but I can only imagine the challenges Elisa and Alice might have faced as female engineers in those days, just as female scientists or female doctors had a whole stream of male criticism and prejudice to swim up against.
I assume that there were some female engineers before 1900, though perhaps not with an official engineering degree; after all, inventors have been around forever and it is no great leap of imagination that some of those inventors were women. And you might argue that we don’t really know any famous female engineers because they haven’t contributed anything major, but I will argue back that a lot of progress happens in little bits and every little contribution has been necessary to get to those major leaps. (Come to think of it, I don’t think I can name any great engineers off the top of my head.)
As there are quite some great female scientists, there are some great female engineers, and naming the first ones is only the start of a long list, that I am positive will grow longer in the future. Perhaps one day, I’ll find my name on that list. (I doubt it, but it can’t hurt to be ambitious, eh.)

More than Sci-Fi

We live in exciting times. Technology that novelists and script writers could only dream of, now exists without us being amazed about it every single day. We have computers, that make immensely complicated calculations and simulations for us all the time. We send people into space and leave them there for months. We can talk to someone on the other side of the world with a simple click on a green phone logo, we can even see them if we want. We use the touch of our finger on a screen to control our devices. We ask our phone questions and it talk backs to give us the answers. We are able to step into virtual reality without getting nauseous. We send out cars that can drive themselves to map our streets. We are able to manipulate single genes, single molecules, single atoms.
Seriously, how are we not amazed every single day?
With all that has been achieved up to now, I can’t help but wonder: “What’s next?” Which crazy science fiction technology will we turn into reality tomorrow? Will humans soon be inhabiting another planet? Will some one create a working lightsaber?
Will we ever be able to travel through time?
I’ve dreamed about this. Not literally –  though maybe I have, I just never remember my dreams so there’s no way to tell – but conceptually. I love reading about it. I love watching movies about it. I love having discussions about the paradoxes it could create. But in the same way that I know the dinosaurs in Jurassic park aren’t realistic, I know it cannot and probably never will be real.
See how I said probably? Did you notice that spark of hope?
To start with, there’s the way my friend (oh wow, his last post is also about SciFi!) states that he’s travelling through time and space at a constant forwards speed, as we all are. So in that sense, we’re all travelling through time, slowly. More interestingly, by travelling through space at a high speed, one would be passing through time at a different speed than others, because the space traveller would have aged less than anyone who had stayed on earth. This idea is called the twin paradox (recently used to explain how Luke ends up being younger than Leia, even though they’re twins) and is due to time dilation, an aspect of special relativity where time slows down when moving at near light-speed speeds. (If you ever have the chance to ask Lieven Scheire to explain special relativity to you, don’t miss it, it’s genius.) So we are able to travel through time at different speeds, and essentially travelling little bits into the future, and renders me hopeful that more sophisticated time travel could be possible.
How would this work? It’s amazing to think that when we look into space, we’re actually looking back in time. Could it ever be possible to travel back in time as well? (I would think that if we’d like send people to travel through space beyond our solar system, travelling through time could be a prerequisite, that is if we want to actually have the same people coming back to tell us what they’ve seen.) Extrapolating from time dilation, we could imagine that travelling at a speed faster than light would allow time reversal. Unfortunately, we don’t even have the technology to travel as speeds close to the speed of light. And that’s not even mentioning that “faster than the speed of light” is not really a thing. (For now? <– See that spark of hope again?)
Another option would be travelling through wormholes, which is a connection between two different points in space time. Unfortunately, we’re not really sure those things exist, so that’s not really a possibility either.
Or perhaps we could build an infinite improbability drive, or a ship that moves time and space around us while remaining stationary. Or have a space ship that’s actually a living creature that propels us through the wibbly wobbly timey wimey thing. Or, I don’t know, a time travelling car?
But if it was up to me, I would tackle time travel differently. I would use a bath tub to travel through time, and incidentally space. (And a friend and myself came up with this idea before that movie about the hot tub time machine came out!)

Image of me and my friend at a poetry competion when we were 9 or 12. We're wearing pyjamas and have a time travelling bath tup with us.
See? Proof!

I guess for now I’ll just have to stick to fiction and keep on dreaming…

“Somewhere, something incredible is waiting to be known.”

… and all it takes is for someone to show it to the world.
Pursuing a career in research involves more than working in a lab or sitting behind a computer all day, it also involves disseminating results and promoting the research. Within the scientific community, communicating research happens through the publication of papers and participation at conferences, but it is equally important to engage to the general public through outreach activities. Part of my PhD project includes participating in outreach, and I have to say I’ve quite enjoyed the projects I’ve been involved in so far (even though I’ve actually not done any outreach yet, just preparation of). Therefore, a bit of internet ramble on outreach.
1. What is outreach?
In this context, I guess outreach can be defined as raising awareness on a certain topic, such as science or academic research. It involves disseminating information about that topic to the general public and people outside the field to increase understanding and interest. Additionally, it could help engage children to the field. Outreach tools would include advertisement leaflets, newsletters, stalls or exhibitions in community centres, university open days, and the organisation of lectures and workshops at schools. Just to give a few examples.
2. Why even do research?
There is a discrepancy between how science is communicated through media and the actual reality of the research. Increasing the understanding of the topics of research, how research is done and how results are generally interpreted can perhaps help solve this problem. Additionally, outreach towards primary and secondary school pupils can perhaps shed a light on how research works and open up prospects of future studies and jobs. Research isn’t at all like the science you learn in school, and it can help get a few nerds enthusiastic about pursuing a career in science by showing them what’s in store.
3. Does outreach actually have an effect?Meme of Jesse from breaking bad saying Yeah Science
Let’s hope so. I’m sure there’s numbers out there, but I don’t know how to find them. And as I haven’t actually participated in any events yet, I can’t draw on personal experience. But even if all outreach does is raise awareness, I think that’s already a worthy cause. And if I can get even one child enthusiastic about science, I would consider that an accomplishment. “Did you know you can actually walk on water, if only you add enough cornstarch and turn it into a non-Newtonian fluid, isn’t physics awesome?”
4. My favourite outreach project
I guess it all started when I was 17 and went to the university open days. I already knew what I wanted to study, it wasn’t a hard choice, but had never considered anything further than the 3 year bachelor. Something a master student told me that day just stuck. She was studying nanoscience and when we asked her why, her answer was something along these lines: “It’s just fascinating. You know how the universe is infinitely large, well the nanoworld is sort of the same, just infinitely small.” And I could never get that out of my head.
An extract of my motivation letter to do my own master in nanoscience:

“I have always been fascinated in the aspect of infinity: the infinity of the universe, the infinite amount of atoms inside it, and the infinite amount of even smaller particles we’re only just beginning to understand. I have read several books on astrophysics in my spare time, for example “The Universe in a Nutshell” by Stephen Hawking, and have come to understand that there is a great analogy between the infinity of the universe and the infinity of what happens on atomic scale. The study of the infinitely small is a field that is particularly intriguing to me.”

I got in and 3 years later I was asked to get involved in a project linking images from outer space to images of “inner space”, i.e. the world inside a cell. Think about it, haven’t you ever seen a picture of a cell and though that it looked like a far away galaxy? Or noticed that certain patterns and structures seem to reappear at every size dimension? It’s almost uncanny how images on such different size scales can look so alike. As an example, some time ago I came across the following image on my second favourite waste-of-time website:

The images on the left are representations of “the Flower of Life” as described in Sacred Geometry. The images in the middle are of structures in outer space, the images on the right depict multiple cell divisions.

I guess it suffices to say that I didn’t need much convincing to get into this project.
So, the Outer Space Inner Space (OSIS) project makes the link between the macroscopic world of outer space and the microscopic world as viewed through a microscope. We (a bunch of people from different schools within the University) are planning to convert the Mills Observatory seminar room into a platform for multimodal and immersive engagement. This will include a room-filling presentation screen to show images of the macro and micro cosmos, and space for workshops and exhibitions. It will also feature human-computing interfaces, ensuring that all audiences can experience and interact with the presentations. Within this framework, we also plan to organise activities within the International Year of Light. We have already started setting up an exhibition that aims to teach the general public about the principles of optics, and how this can be used to look at both things that are very far away as things that are very small. As my supervisor once pointed out: there’s not much difference between trying to look at something very small or trying to look at something very far away. A lot of principles in astronomy are being applied to microscopy as well, such as adaptive optics. And to throw in another quote, this one’s by Oliver Heaviside:

“There is no absolute scale of size in the Universe, for it is boundless towards the great and also boundless towards the small.”

I’m involved in a few other outreach projects as well, this blog might be considered as one of them I guess, though I’m not always – not to say hardly ever – talking about science or my life as a researcher. I’m involved in another project, in which we will try to organise a lecture series on the topic of “Science of Sci-Fi movies,” exploring the reality and feasibility of science and technology that appears in science fiction popular culture, and hopefully proving that some these nerd’s dreams have the potential to become reality. Finally, next month I will be participating in a “Bright Club” training, in my own small effort to prove that scientists can be funny too.

End of internet ramble.

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This post is based on an article that I’ve written for the PHOQUS newsletter that will be published soon, I have therefore plagiarised myself and apologise for anyone who has or will read certain sentences and ideas twice.
The quote in the title is attributed to Carl Sagan.

Sunniest city in Scotland (?)

I feel like I haven’t emphasised the “bagpipe”* aspect of this blog a lot, so a short thought-train on Scotland, for a change:
I remember interviewing for the job here, and a professor that had lived his in California before moving to Dundee, told me that the Scottish weather is exactly how it’s always portrayed: dreary. However, a Dutch professor assured me that it wasn’t too bad. I concluded that it’s just a matter of what you’re used to and that I’d probably do just fine.
Additionally, I have been told over and over again that Dundee is the sunniest city in Scotland. I started to consider myself Dundonian enough to claim the same someone asks me about Scottish weather (maybe unsurprisingly, this is one of the first questions I’m asked after telling people that I live in Scotland). I usually say something along the lines of “Well, I live in the sunniest city of Scotland you know, though that maybe doesn’t mean that much,” and then proceed to the most recent analogy I have conceived; It’s like saying “the best american chocolate” (well, I guess if you consider Hershey’s chocolate…) or “the best glass of Heiniken I’ve ever had” (yeah, best glass of water you mean?). After that, I usually add: “But seriously, it’s really not that bad.”
So I just spent an extensive 5 minute web-based research trying to confirm that Dundee really is the sunniest city of Scotland.
There are claims that Glasgow is the sunniest city, I found another article saying Aberdeen has the most hours of sunshine. The ever trustworthy wikipedia indeed says that Dundee is the sunniest city in Scotland [citation needed], so that doesn’t help much either. Other sites make similar (unverified) claims. A weather site tells me that Dundee has 1426.3 hours of sunshine each year, which is 0.3 hours more than Edinburgh and about 200 more than Glasgow. However Aberdeen had an average of 1435.7 hours between 1981 and 2010, according to the same site. (I didn’t look any further.)
So have I been telling lies? Do I not live in the sunniest city in Scotland? It is clear that the East coast is the place to be, if you do happen to end up in Scotland for whatever reason, and it is also clear that you have to be prepared for every single type of weather (or season) within a day, so dressing in layers and having an umbrella on standby are musts.
In the end it doesn’t really matter. I took my refurbed bike for a first test drive the Sunday before last to Broughty Ferry. It was lovely weather for a 5 mile trip to a lovely beach. I encountered a Finnish cyclist, who had just embarked on a 4-week bike tour of Scotland, I think this was his day two. We both got lost at the same point (apparently the solution to opening to locked gate on our path was ringing the bell), and once we got back on track – national cycle route 1 -, we started chatting. As we split paths (mine led to locking up my bike and getting my feet icy cold wet), he said he was in heaven.
I’m sure that the fact that the sun was shining that day and that it was a pleasant 20-something degrees worked in favour of this sentiment, but I have to say that I was enjoying myself quite a lot as well. I’m definitely looking forward to my next bike outing. I probably wait for the next weekend that the sun is out, and cycle off into my own little bit of heaven.

Getting my feet wet at the beach of Broughty Ferry – check out my awesome bike (oh, it was abandoned and I gave it a clean and a new home, or shed), – view on the river Tay – and the HM Frigate Unicorn 1824 battleship I passed on my way back.

*The tagline used to be: Science, bagpipes, and hopefully a few “Eureka’s”

Cheap is good, almost free is better!

Working in a research environment definitely changes your perspective on the meaning of “cheap” and “expensive”. If paying £194 to go to a festival seems like a lot of money, then consider that you need to pay at least half more to buy an antibody. “Cheap” purchases include most things under, say, £200. And I don’t even want to think about how much money gets spent on consumables like pipets and petridishes. If you want to really do something, you need to buy equipment like microscopes or PCR meters and you can probably buy a car with the same amount of money. Or a jet. Needless to say then, that conducting scientific research is quite an expensive endeavour and it’s no bit surprise that a lot of time goes into applying for grants.
Does it really have to be this expensive though?

The simple answer is: probably.

The fun answer, however, is NO!

I’ll give you an example (and let’s pretend to ignore the fact that I’m too lazy to find another example): easy-to-make, affordable, microscopy lenses. It is quite similar to the water drop hack, which is even cheaper than the method I am going to purpose, but not quite as versatile. I am talking about a lens made out of PDMS.
Bear with me, I am going to explain.
The idea was published last year. It makes use of polydimethylsiloxane (also known as PDMS), which is a elastomer used commonly for making microfluidic devices. The elastomer is made by mixing to reagents together and exposed to heat to allow it to polymerise and form a stable, flexible, clear, rubbery bit of stuff.

An example of a microfluidic device made of PDMS (as a result of a quick google search).

As it is clear and has a high refractive index, making a droplet-shaped bit of this PDMS might very well be used as a lens in combination with a smartphone. And it is cheap, a 1.1 kg bottle of this PDMS might cost a little bit (around £100, but I have already that this is cheap in scientific consumables terms), but you can make so many lenses out of this, it results in about £0,05 per lens. Cheap huh.
So yesterday evening, we spent some time trying to make some of these lenses, which worked quite well. It is very easy to make (we are going to try this as an outreach workshop) and it is also absolutely cool. From just a few hours of messing around – and it is quite a sticky substance to work with – with cover slips, the PDMS, a syringe and a lamp to provide the heat, we made quite some lenses and took quite some pictures.
Wait, I’ll give you another example (it isn’t really though): so using these lenses, you can make a simple (and cheap!) optical trap. An optical trap uses a laser to trap, for example, a bead*. This can be used to measure the viscosity of fluids, measure forces involved in cellular processes (protein folding, motor proteins, adhesion, cytosol viscosity, motility forces, …) or to play a game of tetris. It’s quite a cool technique, and now you can save on costs by making your own lens! (I’m sure the paper will be accessible soon.)
Anyway, this is just to say that research doesn’t always have to be expensive. And obviously it was already fun, but it can be even more fun (who knew)?

CIXCN1-WIAAoKQ6
The result of mucking around. Top left: a PDMS drip lens. Top right and bottom left: pixels from some text on a paper. Bottom right: some of my finger print lines.
Another example: the fabric of my watch. Left is taken in macro mode without the lens (even a bit out of focus), right is with the PDMS lens.
Another example: the fabric of my watch. Left is taken in macro mode without the lens (even a bit out of focus), right is with the PDMS lens.

We live in exciting times. Nostalgia-drenched movies are out now or being released soon. Our childhood hero is returning in the form of theatre. Certain fantasy characters might have actually existed**. Advances that we could only dream of (or write Sci-Fi novels about) seem within reach. And new awesome ways are being developed to make science cheap and accessible for anyone.

Finally, I’ll end with a teaser:

We are currently setting up an outreach project bringing these things together:

cartoon: Microscope and Magnifying glass tell a telescope to "enjoy the little things"
But I enjoy the far away things too! (source)

And it’s already been so much fun! Learn more on twitter or wait until I dedicate a post on the subject (sometime I will!)

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*Yes, this is in no way an adequate explanation of optical trapping. I could say it uses “magic” to trap beads, though I’m sure you won’t believe me.
** Yes, I just rushed over multiple topics that I not-so-secretly wanted to mention in one way or another.

Never say biologists don’t have a sense of humor!

Sometimes, when reading a biology paper, I have to refrain myself from bursting out laughing. Biologists, and more specifically geneticist, come up with the most ridiculous names for genes. Not that I’m complaining, it brightens up even the most boring of papers (though sadly not all names are funny). Here’s a (very!) small selection as an example of biologists’ sense of humour:

  • Really Interesting New Gene (RING)
    The lack of inspiration for naming this gene is in itself quite funny.
  • Sonic Hedgehog
    This was the first funny one I’d come in contact with; at first I just thought I misunderstood the speaker. But it’s a real gene, that when mutated causes fly embryos to be covered with spike-like structures, and thus look like a hedgehog. It also gives the fly supersonic powers.
  • Don Juan
    A gene present in sperm cells of male fruit flies. It makes them extremely sexy.
  • Dissatisfaction
    A gene involved in many aspects of sexual behaviour, apparently not the very useful ones.
  • I’m not dead yet (Indy)
    In reference to a scene in Monty Python and the Holy Grail, when mutated this gene causes an increase in the lifespan of fruit flies. The flies live forever unless swatted.
  • Van Gogh
    In zebrafish, a mutation of Van Gogh results in tiny ears – wait, fish have ears? In fruit flies, a mutation of this gene causes the wings to develop a wing pattern that apparently looks like Starry Night.
  • Tinman
    A mutation in Tinman in mouse embryo results in no heart and the desire to feel love.
  • Casanova
    The result of this gene mutation in zebrafish is that they are born with two hearts, making it a incorrigible womanizer.
  • Spock
    So zebrafish really do have ears, though with a mutation in the Spock gene they end up being pear-shaped. And possibly slightly pointy. It is unsure if the mutated fish are also confused by human emotions, though it is reasonable to believe that most fish probably are.
  • Callipyge
    Sir Mix-a-lot would just love this one. A mutation in this gene results in sheep developing very large hind ends, or “beautiful buttocks” (callipyge in greek), and increased twerking abilities. You got buns, hun!
  • Dracula
    When zebrafish with this mutation are exposed to light, the fish die due to their blood cells bursting (yuck). You probably can kill them by running a wooden stake (or toothpick) through their heart as well.
  • Brainiac
    Fruit flies with this mutation have increased development of brain cells, causing them to realise that a closed window is not an exit.
  • Cheap date
    Give a few drops of alcohol to flies with this mutation and they’ll appear drunk. I’m not sure how many drops it takes to get a wild type fly drunk, but apparently Cheap Date flies are more sensitive to alcohol. They’ll probably be okay with eating some cheap garbage left overs as well, further reducing costs of a date.
  • Ken and Barbie
    Flies with this mutation lack external genitalia. They also have unreasonably small waists and plastic hair dos.
  • Halloween Genes (including disembodied, spook, spookier, shadow, shade, shroud and phantom)
    Mutations in Halloween genes cause flies to grow scary, abnormal exoskeletons, giving them instant status as spiderman nemeses.

A few more honourable mentions: Armadillo, Bagpipe, Bag or marbles, Grunge and Teashirt (fly), Jelly Belly, Seven up, Snafu, Wishful Thinking, Slamdance, Slowpoke, Smaug, Stardust, Grim and Reaper, Shaven Baby, Kryptonite and Superman, and Swiss cheese. If I ever discover a gene (very slim chance), I will do my best to come up with something original, but with all that out there, it will be a challenge.
Extra note: Not only biologists have a sense of humour. There is a theory in physics called “The Hairy Ball Theorem”. Don’t worry, it’s about not being able to brush coconuts (What?). And I’m sure there are more examples out there.

On Growth and Form

Before I start, a short comment on personal growth:
After a quite frustrating day yesterday, I decided to get up bright and early, go for a run and then head to work today. It’s actually a national holiday here (Ascension), but as I have to take my holidays explicitly, and “I’m here for work and not for fun (except for weekends)”, that was my plan. So I was up and ready to leave for my jog, when my flatmate just entered the front door, after a night out. Made me think.
I guess I’m a “real grown-up” now…
But now, On Growth and Form.
I have discovered that Dundee has had quite an interesting inhabitant. His name is D’Arcy Wentworth Thompson. I had never heard of him until sometime last year when we went out to dinner in a restaurant called The D’Arcy Thompson. A plaque on the wall informed us he was a biology professor in Dundee (at the time the university was still part of the University of St. Andrews) around 1900.
Sometime later, I went to a talk about penguins, more specifically about the two penguins that Dundonian Arctic explorers had brought back from their trip south. The penguins had gone through quite a bit, one even was the official mascot of a student faculty club, but they are now on display in the D’Arcy Thompson Zoology Museum on the campus of the University of Dundee. We went to go see the museum after the talk, it’s a room stuffed with, well, stuffed animals. Quite an impressive collection, including a giant crab. (Giant means more than a meter across. Imagine running into a wild one!)

A stuffed penguin in a vitrine of a zoology museum
The penguin before it went missing. (ca. 1900)

But it wasn’t until last week that I realised how interesting Mister D’Arcy really was – and I just realised that sounds like a sentence from Pride and Prejudice. A research letter in Nature Physics on the combined mechanics of cells in tissues mentions the following:

In 1917, D’Arcy Thomson published a treatise On Growth and Form in which he suggested that morphogenesis could be explained by forces and motion – in other words by mechanics.

You might recall that my PhD is about the mechanics of gut cancer. And I didn’t know about D’Arcy, shame on me! In the meantime I’ve tried to get my hands on the book, not too difficult because there are some on line pdfs circulating with the whole thing. Unfortunately, I’m the worst at reading from a computer screen, so I haven’t gotten very far*, but it seems that Mister D’Arcy was quite interesting indeed. His 1136-paged book reads a bit a philosophy book (or it does in the first 304 pages). He tells the story – for it’s written like a story – of how the mechanics in biology is quite similar to the mechanics of inanimate bodies, and that growth and morphology can essentially be explained by physics. He gives a whole list of examples, where he makes analogies between biological systems and physical systems. He admits that this will not explain every detail of biology, but that it is possible to explain certain simpler phenomena of organic growth and form using mathematical and physical descriptions. His studies on fractal patterns and linear transformations (rotation, translation, shearing) have been important for image analysis, architecture, mathematics and probably many other fields.

Left: sketch of a fish in a grid. Right: transformation of the fish showing the deformed grid
Mathematical transformations of homologous features in fish.

Then how had I never heard of Mister D’Arcy (I realise it should be Mister Thompson but that just doesn’t have that ring to it)? Luckily I’ve figured my lack of knowledge on time and can rectify that mistake. D’Arcy had innovative ideas, that have been pushed to the sidelines by molecular and genetic research in morphogenesis. Nevertheless, is book is merely descriptive, so there is still much to be learned. Which is where projects like mine come in.
Hurray, I have a purpose!

D'Arcy Thompson holding a skeleton of a parrot
Thank you Mister D’Arcy!

*If anyone knows where I can get my hands on a good hard copy, please let me know! Amazon only cells “bad quality and incomplete” versions, so it’s proving quite difficult.

How to win a Nobel Prize

I’ve mentioned a while ago that I’d write a post focussing on how to win a Nobel Prize. Recently, a 10 simple rules paper (something I mentioned in that same post) was published on that exact subject, reminding me that I should step on it and write already.
So, here we go, inspired by conversations with friends and that paper I just mentioned (1), some guidelines on how to win a Nobel Prize.

  1. Eat chocolate and drink milk.
    It has been suggested a few years ago that the suspicious relation between the number of Nobel Prize winners in Switzerland might be related to chocolate consumption (2). Obviously, as a Belgian (though the chocolate consumption of Belgians seems to be suspiciously low) and chocolate fiend, I found this very interesting. A follow-up study suggested that the consumption of milk (3) might also play a role, something I don’t expect to be a problem either. In the end, both articles were more of an illustration of how correlation and causality can easily get mixed up in (amateur) statistics, rather than encouraging people to stock up on milk and coco. Eating habits aren’t very likely to increase your chances of winning a Nobel Prize, but one can hope that loving chocolate can’t hurt…

    Correlation between Countries' Annual Per Capita Chocolate Consumption and the Number of Nobel Laureates per 10 Million Population
    Correlation between Countries’ Annual Per Capita Chocolate Consumption and the Number of Nobel Laureates per 10 Million Population (2).

    Correlation between countries’ annual per capita milk consumption and the number of Nobel laureates per 10 million population (3).
  2. Choose your contacts wisely 
    Nowadays, most Nobel Prizes are won by a group of 3 people. Additionally, most science is done through collaborations nowadays. Different backgrounds, expertise, points of view and even different disciplines mixed together, provide for good science and innovative discoveries. So collaborate, but not with too many people. If you’re not yet in a position to collaborate (I assume that’s easier once you’re a principal investigator), choose your workplace wisely. Perhaps working in the same institution or even directly in the laboratory of a Nobel Prize laureate and gain from his or her experiences, will provide you with the inspiration to win your own Prize. For example, 9 staff members of the Medical Research Council (MRC) Laboratory in Cambridge have won Nobel Prizes. And if you can’t find such a position, another strategy is to pick your family wisely. Sometimes children of Nobel Prize winners go on to win the prize themselves, as has been shown already seven times. But since choosing what family you’re born into isn’t exactly practical, perhaps consider marrying a prospective Nobel Prize winner, as four married couples have won the prize, as was the case for the Nobel Prize in Physiology and Medicine last year (1).
  3. Serendipity.
    A topic I have brought up before but sheer luck, or a certain degree of serendipity, seem to have an effect on your chances of winning a Nobel Prize. Andre Geim and colleagues were messing around with some scotch tape and that led to a Nobel Prize, and penicillin is a similar example. Sometimes things going wrong are not such a bad thing. Often great discoveries are made “by accident”. If your experiment doesn’t go as expected, perhaps it’s time to re-analyse: is it through faulty protocols or maybe because of wrong assumptions. Challenge everything you do, ask questions, and if something cool and unexpected happens, maybe this is something worth looking in to?
  4. Life sciences are the bomb.
    The article (1) mentions that Biology is the field in if you’re aiming for a noble prize. There’s still so much to be discovered in biology, and it’s forever changing (evolution, my dear Watson). It often needs interdisciplinary approaches, making it easy to do collaborative research (see point 2). And there are two Nobel Prize categories you can aim for, so more chance!
  5. Just have fun.
    But most importantly (and strongly emphasised in (1)), don’t aim for a Nobel Prize. Science shouldn’t be about winning prizes or aiming for fame. Science and research are about curiosity, wanting to know how the world works, finding solutions that can help humans and the earth, and most of all, about having fun. You should be in research because that is what you love. If you feel a great sense of accomplishment when you successfully finish an experiment or make a beautiful and informative microscopy image, if you squeal like a fan girl when you read about novel scientific breakthroughs, if you make plans with your friends to do “Friday afternoon experiments” (yes, that’s doing research just because you want to), then go into research. Perhaps you’ll win a Nobel Prize one day. Probably not. And who cares, you’re doing what you love.

Related to that, Switzerland is great. In the week I’m busy busy busy working, in the weekends I feel like I’m on holiday, riding on boats on Zürichsee and whatnot. In this country where people actually stop to let you cross the road or hold tram doors because they think you’re trying to catch it, I feel quite at home. Maybe it’s because of the wonderful weather and the delicious chocolate, but the first weeks have been great. I think I will enjoy my time here.

A view of the Alpes and the lake of Zürich (taken on the lake)
A view of the Alps and the lake of Zürich (taken on the lake!)

References and Inspirations:
(1) Roberts RJ (2015) Ten Simple Rules to Win a Nobel Prize. PLoS Comput Biol 11(4): e1004084. doi:10.1371/journal.pcbi.1004084
(2) Messerli FH (2012) Chocolate consumption, cognitive function, and Nobel Laureates. N Engl J Med 2012; 367:1562-1564. doi:10.1056/NEJMon1211064
(3) Linthwaite S, Fuller GN (2013) Milk, chocolate and Nobel prizes, Pract Neurol13:63. doi:10.1136/practneurol-2012-000471

Competition, conversation and collaboration

photo of a city (Basel) along a river
Last weekend I moved to Basel for a two month impersonation of “guest researcher” in a nanobiology lab.
Before I even get to the point, I want to say that Basel is awesome. Except for the evening I arrived, the weather has been the perfect example of “Spring is in the air” and Basel’s traditional emblem and guardian creature is a Basilisk. First of all, this city has a guardian creature. Second of all, this creature appears in one of my favourite books (I was going to say in my favourite septology but I’m pretty sure that’s not a word, so I decided to refer to Newt Scamander’s Fantastic Beasts and where to find them instead). A quick look at the various statues scattered around the city – most of them spouting water – as well as the wikipedia page – I’m such a professional -, taught me that unlike my expectations of a giant snake living in sewage under girls bathrooms, a basilisk looks more like a dragon with a bird’s head. It does still have Medusa-like statue making abilities or killing-at-a-glance powers (depending on the source) and a weakness for weasels/Weasleys. Come to think of it, I’m pretty sure the emblem of Dundee involves dragons and that of Scotland in general has a unicorn. I sure know how to pick my magical creatures. (That of my home town is a boring old swan though…)
In any case, moving to a new lab, albeit for only two months, reminds me of one of the things I love about being in science (as far as I can call my current career “being in science”. A friend of mine basically covered this same topic in her blog recently and I’ll probably just plagiarise repeat some of what she said, but one of the things I love is moving around for conferences, lab visits or even just a new job (as I have for my PhD) to not only explore the world but also explore the minds of all the amazing people I encounter. I might be because I’m still quite young (no need to settle down yet), adventurous at heart (always moved around a bit) and get amazing opportunities (an international and interdisciplinary PhD), but I also believe that the future of science lies in international, collaborative and interdisciplinary research. Also, it’s surprisingly refreshing to pack all you basic needs in one suitcase and just step on a plane.
The thing is, I’ve heard disconcerting stories about research groups not willing to present unpublished work at conferences in fear their ideas will be stolen. Or people naming collaborators as reviewers when submitting papers, while steering clear of their competitors. Science seems to exist in an atmosphere of suspicion and nepotism (though I like the Dutch word vriendjespolitiek – literally friends politics – better) where results and ideas are only shared with collaborators but hidden from competitors.
Of course there’s merit in a bit of healthy competition, it drives people to be ambitious and bring out the best in themselves, but as it is becoming increasingly clear that science is no longer a one-man’s-job (though my friend that I mentioned earlier is well on her way of becoming a homo universalis), I am supporter of more collaborative and open science. I for one have had great ideas by conversing with other people, inside and outside my field of research (and so we bring in the aspect of interdisciplinary research as well). Bouncing ideas off each other, seeing different points of view and geeking out during lunch breaks brings out the best of us, or at least of me.
Well, in any case, I am glad to be here in Basel, these first few days have already been amazing and mind opening and I’m sure there are many more inspiring moments to come.
I’ll leave you with this quite funny looking basilisk. It doesn’t have any jet black scales or horcrux-destroying fangs, but I’d still not look in the eye…
Artist rendering if a basilisk: somehow a cross between a dragon and a chicken.